C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2280634
The present invention provides two human p24 vesicle trafficking proteins (designated individually as Hp24-1 and Hp24-2 and collectively as Hp24) and polynucleotides which identify and encode Hp24. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Hp24 and a method for producing Hp24. The invention also provides for agonists, antibodies, or antagonists specifically binding Hp24, and their use, in the prevention and treatment of diseases associated with expression of Hp24. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Hp24 for the treatment of diseases associated with the expression of Hp24. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Hp24.
Cette invention concerne deux protéines humaines p24 d'acheminement par vésicules (individuellement appelées Hp24-1 et Hp24-2 et collectivement appelées Hp24) ainsi que des polynucléotides qui identifient et codent Hp24, des vecteurs d'expression et des cellules hôtes produits par génie génétique qui contiennent les séquences d'acides nucléiques codant Hp24 et un procédé de production de Hp24; des agonistes, des anticorps ou des antagonistes liant spécifiquement Hp24 et leur utilisation dans la prévention et le traitement de maladies associées à l'expression de Hp24; l'utilisation de molécules non codantes contre des polynucléotides codant Hp24 pour traiter des maladies associées à l'expression de Hp24; et des dosages de diagnostic dans lesquels on utilise le polynucléotide, des fragments ou le complément de ce dernier et des anticorps liant spécifiquement Hp24.
Bandman Olga
Goli Surya K.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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