Peptides from the tt virus sequence and monospecific...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/01 (2006.01) A61P 31/20 (2006.01) C07K 16/08 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2370495

The peptide having the amino acid sequence SEQ ID NO:1, and optionally this peptide in mixture with one or more peptides SEQ ID NO:3 - 11, is described. All these peptides correspond to regions of the genomic TT virus sequence. Further, monospecific antibodies binding to the TT virus are disclosed. The peptides may be coupled to a carrier and/or label, or immobilized on a solid phase. The peptide or peptide mixture, or the monospecific antibody may be used in a medicament or in diagnostic kits. The peptide or peptide mixture may also be used for immunization of a non-human mammal to produce monospecific antibodies directed against TT virus.

L'invention porte sur le peptide présentant la séquence d'acide aminé SEQ ID NO:1, et facultativement sur ledit peptide mélangé à un ou plusieurs peptides présentant la séquence SEQ ID NO:3 - 11. Tous ces peptides correspondent à des régions de la séquence du génome du virus TT. Elle porte également sur des anticorps monospécifiques se fixant au virus TT. Les peptides peuvent se coupler à un support ou à un marqueur, ou être immobilisés sur une phase solide. Le peptide, ou le mélange de peptides, ou l'anticorps monospécifique peuvent s'employer dans des médicaments ou dans des trousses pour diagnostics. Ils peuvent également servir à immuniser un mammifère non humain pour produire des anticorps monospécifiques dirigés contre le virus TT.

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