C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/635 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/87 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2408559
Described herein is the identification of two polymorphic isoforms of the gene encoding the PTHrP protein, of the allelic proteins, of a first polynucleotide comprising the polymorphic domain corresponding to SEQ ID NO:2 and comprising a first polymorphic position, of a second polynucleotide comprising a second polymorphic domain and corresponding to SEQ ID NO:7 which encode for two variants of the PTHrP protein; also described is the use of these genes, alleles or polynucleotides to determine the risk of tumor in animals and humans and genetically modified cells and non-human animals.
L'invention concerne l'identification de deux isoformes polymorphes du gène codant pour la protéine PTHrP, des protéines allèles, d'un premier nucléotide comprenant le domaine polymorphe correspondant à la séquence n·2 et comprenant une première position polymorphe, et d'un second nucléotide comprenant un second domaine polymorphe et correspondant à la séquence n·7 qui code pour deux variants de la protéine PTHrP. Elle concerne aussi l'utilisation de ces gènes, allèles ou polynucléotides afin de déterminer le risque de tumeur chez les animaux et chez les humains, ainsi que des cellules génétiquement modifiées et des animaux non humains.
Dragani Tommaso A.
Manenti Giacomo
Istituto Nazionale Per Lo Studio E. La Cura Dei Tumori
Marks & Clerk
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