C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/454 (2006.01) A61K 31/519 (2006.01) A61K 49/00 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2757723
The present invention describes an association between genetic polymorphisms in the ABCC2 gene and a predisposition to prolongation of the QT interval, and provides related methods for the prediction of such a predisposition, the administration of QT interval-prolonging compounds to individuals having such a predisposition, and determining whether a compound is capable of inducing QT prolongation.
La présente invention décrit une association entre des polymorphismes génétiques dans le gène ABCC2 et une prédisposition à la prolongation de l'intervalle QT, et porte sur des procédés apparentés pour la prédiction d'une telle prédisposition, l'administration de composés prolongeant l'intervalle QT à des individus ayant une telle prédisposition et la détermination du fait qu'un composé est capable ou non d'induire une prolongation de QT.
Lavedan Christian
Licamele Louis
Volpi Simona
Shapiro Cohen
Vanda Pharmaceuticals Inc.
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