C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/70 (2006.01) A61K 38/48 (2006.01) C07K 14/315 (2006.01) C12N 15/57 (2006.01) C12N 15/79 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2277554
The present invention is related to the field of biotechnology and genetic engineering techniques, particularly to a method for obtaining mutants obtain from streptokinase, to the molecules obtained from this method, as well as the expression vectors and microorganisms for recombinant obtaining. The object of the present invention is to achieve streptokinase mutants from modifications of skc-2 gene coding for streptokinase SKC-2 (Heberkinase®), such that the obtained mutants conserve their capacity for plasminogen activator complex formation having reduced antigenicity, that could constitute preferred alternatives to native streptokinase for thrombolytic therapy. The molecules obtained from present invention can be used in the treatment of disorders as myocardial infarct, pulmonary thromboembolism, surgical complications and other cases of thrombosis.
de La Fuente Garcia Jose
Escalona Elder Pupo
Fernandez Masso Julio Raul
Griego Martha de Jesus Gonzalez
Madrazo Isis Del Carmen Torrens
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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