C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2609077
The present invention relates to a novel method to promote regeneration or repair of the central or peripheral nervous system following injury The present invention concerns the use of a leucine-rich, glioma- inactivated protein (LGIn), or an analog or derivative thereof, to promote the regeneration or remyelination of neurons after injury to the central nervous system LGIns are endogenous proteins secreted by central neurons that promote regeneration of neurons after injury to the central nervous system The present invention includes an assay to measure the interaction of LGIn with LINGOn and p75NTRn as well as to identify factors that enhance or disrupt these interactions The invention further includes cell lines capable of expressing LGIn, LINGOn and p75NTRn molecules, as well as the proteins purified from these cells.
L'invention concerne un nouveau procédé qui favorise la régénération ou la réparation du système nerveux central ou périphérique après une lésion. De plus, l'invention concerne l'utilisation d'une protéine inactivée par gliome, riche en leucine (LGIn), ou un analogue ou un dérivé de celle-ci, pour favoriser la régénération ou la remyélinisation des neurones aprés lésion du système nerveux central. Les LGIn sont des protéines endogènes secrététées par les neurones du système nerveux central, qui favorisent la régénération des neurones après la lésion du système nerveux central. Par ailleurs, l'invention comprend un dosage qui permet de mesurer l'interaction des LGIn avec LINGOn et p75NTRn, ainsi que l'identification des facteurs qui améliorent ou qui perturbent ces interactions. L'invention concerne en outre des lignées cellulaires capables d'exprimer les molécules de LGIn, LINGOn et p75NTRn, ainsi que des protéines purifiées de ces cellules.
Barker Philip A.
Fournier Alyson
Morante Redolat Jose Manuel
Perez-Tur Jordi
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Mcgill
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