Soluble ctla4 mutant molecules and uses thereof

Details Soluble ctla4 mutant molecules and uses thereof Soluble ctla4 mutant molecules and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 37/02 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2409748

The present invention provides soluble CTLA4 mutant molecules which bind with greater avidity to the CD80 and/or CD86 antigen than wild type CTLA4 or non- mutated CTLA4Ig. The soluble CTLA4 molecules have a first amino acid sequence comprising the extracellular domain of CTLA4, where certain amino acid residues within the S25-R33 region and M97-G107 region are mutated. The mutant molecules of the invention may also include a second amino acid sequence which increases the solubility of the mutant molecule.

L'invention concerne des molécules CTLA4 mutantes solubles qui se lient plus avidement à l'antigène CD80 et/ou CD86 qu'au CTLA4 de type sauvage ou au CTLA4Ig n'ayant pas muté. Les molécules CTLA4 solubles ont une première séquence d'acides aminés comprenant le domaine extracellulaire de CTLA4, où certains résidus d'acides aminés ont mutés dans les régions S25-R33 et M97-G107. Selon l'invention, les molécules mutantes peuvent également comporter une deuxième séquence d'acides aminés, qui augmente la solubilité de ladite molécule mutante.

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