Thiazole compounds as integrin receptor antagonists derivatives

Details Thiazole compounds as integrin receptor antagonists derivatives Thiazole compounds as integrin receptor antagonists derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/427 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2510084

The present invention relates to pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the .alpha..nu..beta.3 and/or the .alpha..nu..beta.5 integrin without significantly inhibiting the .alpha..nu..beta.6 integrin.

La présente invention concerne des compositions pharmaceutiques renfermant des composés de formule (I) et des méthodes permettant d'inhiber ou d'antagoniser sélectivement l'intégrine .alpha.<SB>V</SB>.beta.¿3? et/ou l'intégrine .alpha.¿ V?.beta.¿5 ?sans inhiber considérablement l'intégrine .alpha.¿ V?.beta.¿6?.

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