Quinoline and quinoxaline compounds which inhibit...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 241/44 (2006.01) A61K 31/498 (2006.01) A61L 31/08 (2006.01) A61L 31/16 (2006.01) C07D 241/42 (2006.01)

Patent

CA 2291728

This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor tyrosine kinase and/or Lck tyrosine kinase, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a patient suffering from or subject to disorders/conditions involving cellular differentiation, proliferation, extracellular matrix production or mediator release and/or T cell activation and proliferation.

L'invention concerne des composés quinoline/quinoxaline inhibant la tyrosine-kynase de facteur de croissance dérivé des plaquettes et/ou la tyrosine-kinase Lck, des compositions pharmaceutiques renfermant ces composés, et l'utilisation de ces composés pour le traitement de patients souffrant ou sujets à des troubles/états associés à la différentiation et à la prolifération cellulaire, à la production de la matrice extracellulaire ou à la libération des médiateurs chimiques et/ou à l'activation et à la prolifération des lymphocytes T.

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