Thioaryl sulfonamide hydroxamic acid compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 295/14 (2006.01) A61K 31/18 (2006.01) A61K 31/197 (2006.01) A61K 31/216 (2006.01) A61K 31/27 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/423 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/4406 (2006.01) A61K 31/4409 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/4465 (2006.01) A61K 31/4545 (2006.01) A61K 31/535 (2006.01) A61

Patent

CA 2282399

A thioaryl sulfonamide hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated thioaryl sulfonamide hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

La présente invention concerne un composé d'acide hydroxamique sulfonamide thioaryle qui inhibe notamment une activité de métalloprotéase matricielle (MMP). La présente invention concerne également un procédé de traitement qui consiste à administer le composé d'acide hydroxamique sulfonamide thiaryle en question, à raison d'une dose efficace destinée à inhiber l'activité d'une enzyme MMP, à un hôte présentant une condition associée à une activité pathologique de métalloprotéase matricielle.

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