Formation of novel erythropoietin conjugates using...

Details Formation of novel erythropoietin conjugates using... Formation of novel erythropoietin conjugates using...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/52 (2006.01) C07K 1/00 (2006.01)

Patent

CA 2527665

The invention provides biologically active erythropoietin (EPO) conjugate compositions wherein a transglutaminase reaction is employed to covalently and site specifically conjugate the EPO molecule to a non-antigenic hydrophilic polymer that can also be covalently linked to an organic molecule either of which modification increases the circulating serum half-life of the composition.

L'invention concerne des compositions de conjuguées d'érythropoïétine (EPO) biologiquement actives. On utilise une réaction transglutaminase pour conjuguer la molécule d'EPO de manière covalente et régiospécifique à un polymère hydrophile antigénique pouvant également être lié par covalence à une molécule organique, l'une quelconque de ces modifications permettant d'augmenter la demi-vie sérique de la composition.

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