C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A01N 37/18 (2006.01) A61K 38/00 (2006.01) C07K 7/00 (2006.01) C07K 14/475 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2498044
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
On a déterminé que le clivage de métalloprotéases d'un propeptide de myostatine provoque l'activation, dans une forme active, d'une myostatine inactive latente. l'invention concerne des procédés permettant d'identifier des agents qui modulent l'activation médiée par la métalloprotéase de la myostatine, ainsi que les agents identifiés au moyen desdits procédés. L'invention concerne également des procédés de modulation de la croissance musculaire dans un organisme, par augmentation ou diminution du clivage médié par métalloprotéase d'un propeptide de myostatine.
Tomkinson Kathy
Wolfman Neil
Torys Llp
Wyeth
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