Reagents and methods useful for detecting diseases of the...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2358800

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BS322 and transcribed from breast tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast, such as breast cancer. Also provided are antibodies which specifically bind to BS322-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS322 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

L'invention concerne un ensemble de séquences d'ADNc contiguës et partiellement superposées, ainsi que des polypeptides appelés BS322, codés par ces séquences et transcrits à partir d'un tissu mammaire. Ces séquences sont utiles pour détecter, diagnostiquer, déterminer le stade, surveiller, pronostiquer, imager in vivo, prévenir ou traiter, ou déterminer la prédisposition d'un individu à des maladies ou affections mammaires, telles que le cancer du sein. L'invention concerne en outre des anticorps qui se lient spécifiquement à un polypeptide BS322 codé ou à une protéine, ainsi que des agonistes ou inhibiteurs qui neutralisent l'action du polypeptide BS322 spécifique au tissu, lesdites molécules étant utiles pour le traitement thérapeutique de maladies mammaires, de tumeurs ou de métastases.

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