A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/56 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2256721
The present invention relates to pharmaceutical compositions for nasal administration comprising: a) a safe and effective amount of a glucocorticoid selected from the group consisting of beclomethasone, flunisolide, fluticasone, memetasone, budesonide, pharmaceutically acceptable salts thereof and mixtures thereof; b) a safe and effective amount of a fast acting antihistamine selected from the group consisting of acrivastine, carbinoxamine, diphenhydramine, chloropheniramine, brompheniramine, dexchloropheniramine, doxylamine, clemastine, promethazine, trimeprazine, methdilazine, hydroxyzine, pyrilamine, rocastine, tripelennamine, meclizine, tripolidine, azatadine, cyproheptadine, phenindamine, pharmaceutically acceptable salts thereof and mixtures thereof; and c) an aqueous, intranasal carrier wherein the composition is free of capsaicin and, preferably, free of powders or granules. The present invention also relates to a method for the treatment of symptoms associated with seasonal or perennial allergic rhinitis comprising the administration of a safe and effective amount of the intranasal pharmaceutical compositions of the present invention.
Compositions pharmaceutiques d'administration nasale qui comprennent (a) une quantité efficace et sûre d'un glucocorticoïde choisi parmi béclométhasone, flunisolide, fluticasone, mémétasone, budésonide, des sels pharmaceutiquement acceptables et des mélanges desdites substances, (b) une quantité sûre et efficace d'un antihistaminique à action rapide choisi parmi acrivastine, carbinoxamine, diphènhydramine, chlorophéniramine, bromphéniramine, dexchlorophéniramine, doxylamine, clémastine, prométhazine, triméprazine, méthdilazine, hydroxyzine, pyrilamine, rocastine, tripelennamine, méclizine, tripolidine, azatadine, cyproheptadine, phénindamine, des sels pharmaceutiquement acceptables et des mélanges desdites substances et (c) un excipient aqueux intranasal. Ladite composition est exempte de capsaicine et, de préférence, exempte de poudres ou de granules. La présente invention concerne également un procédé de traitement de symptômes associés à la rhinite allergique saisonnière ou apériodique, qui consiste à administrer une quantité sûre et efficace desdites compositions pharmaceutiques intranasales.
Kirby Eades Gale Baker
The Procter & Gamble Company
LandOfFree
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