Methods of treatment of mitochondrial disorders

A - Human Necessities – 61 – K

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A61K 31/70 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2362925

In accordance with the present invention, there are provided methods for the treatment of mitochondrial disorders. Invention methods include the administration of a pyrimidine-based nucleoside such as triacetyluridine, or the like. Also provided are methods of reducing or eliminating symptoms associated with mitochondrial disorders. Mitochondrial disorders particularly appropriate for treatment include those attributable to a deficiency of one or more pyrimidines.

L'invention concerne des procédés de traitement de troubles mitochondriaux. Les procédés de l'invention comprennent l'administration d'un nucléoside à base de pyrimidine tel que triacétyluridine ou similaire. Elle concerne également des procédés pour réduire ou éliminer les symptômes associés aux troubles mitochondriaux, notamment à ceux des troubles mitochondriaux qui sont attribués à la carence en un ou plusieurs pyrimidines.

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