C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/06 (2006.01) A61K 35/14 (2006.01) A61K 41/00 (2006.01) C12N 15/01 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2296366
The invention provides methods and compositions for treating leukocytes to arrest proliferation of the leukocytes and render them ineffective in eliciting graft-versus-host disease (GVHD), but effective to enhance engraftment of allongeneic donor cells and promote destruction of diseased cells or pathogens. Leukocyte compositions and methods of use of these compositions in alleviating disease, facilitating various types of immune reconstitution and immunotherapy, and enhancing engraftment of allogeneic donor cells, are also provided.
L'invention concerne des méthodes et des compositions permettant de traiter des leucocytes de manière à stopper leur prolifération et à les rendre incapables de déclencher des réactions du greffon contre l'hôte, mais capables d'améliorer la greffe de cellules de donneurs allogéniques et d'accélérer la destruction de cellules malades ou d'agents pathogènes. L'invention concerne également des compositions leucocytaires et des méthodes d'utilisation de ces compositions visant à atténuer des maladies, à accélérer plusieurs types de reconstitution du système immunitaire et d'immunothérapies, et à améliorer la greffe de cellules de donneurs allogéniques.
Grass Joshua A.
Greenman William M.
Hearst John E.
Hei Derek J.
Stassinopoulos Adonis
Cerus Corporation
Gowling Lafleur Henderson Llp
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