G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2542033
The present invention relates to a method for identifying a subject at risk of developing hypertensive end organ damage, such as and in particular heart failure, comprising: a) obtaining a biological sample of said subject; b) determining the level of at least one non-myocytal marker in said sample; c) comparing the level of said marker to a standard level; and d) determining whether the level of the marker is indicative of a risk for developing hypertensive end organ damage. The non-myocytical marker preferably is galectin-3 or thrombospondin-2.
La présente invention concerne un procédé d'identification d'un sujet susceptible de développer des lésions hypertensives d'organes terminaux, telles que, et en particulier, l'insuffisance cardiaque. Cette méthode consiste: a) à prélever un échantillon biologique sur le sujet; b) à déterminer le niveau d'au moins un marqueur non myocytaire dans cet échantillon; c) à comparer le niveau de ce marqueur avec un niveau de référence; et d) à déterminer si le niveau du marqueur révèle un risque de développer des lésions hypertensives d'organes terminaux. Le marqueur non myocytaire est de préférence la galectine-3 ou la thrombospondine-2.
Gowling Lafleur Henderson Llp
Universiteit Maastricht
LandOfFree
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