Modulators of odorant receptors

Details Modulators of odorant receptors Modulators of odorant receptors

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2571080

The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.

L'invention porte sur des polypeptides capables de promouvoir la localisation de surface cellulaire du récepteur odorant et l'expression fonctionnelle du récepteur fonctionnel. Cette invention se rapporte également à des dosages pour la détection de ligands propres à plusieurs récepteurs odorants. L'invention concerne également des procédés de criblage de polymorphismes et de mutations de protéine accessoire du récepteur odorant associés à des états de maladie, ainsi que des procédés de criblage d'agents thérapeutiques, de ligands et de modulateurs de ces protéines.

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