A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) A61K 38/55 (2006.01)
Patent
CA 2215234
Pharmaceutical compositions comprising (1) amlodipine, a pharmaceutically acceptable salt of amlodipine, or felodipine; (2) an ACE inhibitor, and, optionally, (3) a diuretic; and/or (4) digoxin. Use of the compositions result in improved morbidity and/or mortality for the treatment of congestive heart failure. Also, methods of treating congestive heart failure in a mammal, especially a human, by co- administration of (1) amlodipine, a pharmaceutically acceptable salt of amlodipine, or felodipine; (2) an ACE inhibitor, and optionally (3) a diuretic and/or (4) digoxin.
Compositions pharmaceutiques comprenant (1) de l'amlodipine, un sel pharmaceutiquement acceptable de l'amlodipine ou de la félodipine; un inhibiteur de l'enzyme de conversion de l'angiotensine; et, facultativement, (3) un diurétique; et/ou (4) de la digoxine. L'utilisation de ces compositions permet de réduire la morbidité et/ou la mortalité dans le traitement des insuffisances cardiaques congestives. Des procédés de traitement d'insuffisances cardiaques congestives chez un mammifère, notamment chez l'homme, sont également décrits, par l'administration conjointe d' (1) amlodipine, d'un sel pharmaceutiquement acceptable d'amlodipine ou de félodipine; (2) d'un inhibiteur de l'enzyme de conversion de l'angiotensine; et éventuellement (3) d'un diurétique et/ou de (4) digoxine.
Cropp Anne B.
Kraska Allen R.
Pfizer Inc.
Smart & Biggar
LandOfFree
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