A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01)
Patent
CA 2535952
The present invention relates to a method of inducing or enhancing the expression of granzyme B in natural killer (NK) cells. The present invention relates also to a use of said NK cells for the preparation of a pharmaceutical composition for the treatment of tumors, viral or bacterial infections or inflammatory diseases. Further, the present invention relates to the use of granzyme B for the treatment of tumors, viral or bacterial infections or inflammatory diseases, wherein the tumor cells or the cells affected by said infection or inflammation express Hsp70 in their cell surface.
La présente invention concerne un procédé d'induction ou d'amélioration de l'expression de granzyme B dans des cellules tueuses naturelles (NK). La présente invention concerne également une utilisation desdites cellules tueuses naturelles dans la préparation d'une composition pharmaceutique destinée au traitement de tumeurs, d'infections virales ou bactériennes ou de maladies inflammatoires. La présente invention concerne également l'utilisation de granzyme B dans le traitement de tumeurs, d'infections virales ou bactériennes ou de maladies inflammatoires, les cellules tumorales ou les cellules affectées par ladite infection ou inflammation exprimant Hsp70 sur leur surface cellulaire.
Multhoff Gabriele
Sim & Mcburney
LandOfFree
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