Methods to identify inhibitors of the unfolded protein response

Details Methods to identify inhibitors of the unfolded protein response Methods to identify inhibitors of the unfolded protein response

C - Chemistry, Metallurgy

40

B

C40B 30/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/34 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) C12N 9/22 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2638735

Methods for identifying compounds that are inhibitors of the unfolded protein response are provided. In particular, the methods identify compounds that inhibit the activity of IRE1.

L'invention porte sur des procédés permettant d'identifier des composés inhibiteurs de réponse aux protéines dépliées. Lesdits procédés permettent notamment d'identifier des composés qui inhibent l'activité de IRE1.

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