A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C12Q 1/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2734678
The present invention concerns a method for identifying a compound which inhibits the activation of RAC GTPase by DOCK5 protein comprising the steps of (i) coexpressing the DOCK5 and the RAC proteins in a cell, wherein said D0CK5 pro-tein induces the conversion of inactive RAC, which inactive RAC is bound to GDP, to active RAC, which active RAC is bound to GTP, (ii) contacting or not said cell with said compound, (iii) determining the conversion of inactive RAC to active RAC in the presence or absence of said compound, and (iv) selecting the compound inhibiting the conversion of inactive RAC to active RAC. Said compound is useful for treating disease-associated bone loss.
L'invention concerne un procédé pour identifier un composé qui inhibe l'activation de la RAC GTPase par la protéine DOCK5, comprenant les étapes consistant à : (i) coexprimer des protéines DOCK5 et RAC dans une cellule, la protéine DOCK5 induisant la conversion d'une RAC inactive, laquelle est fixée à une GDP, en une protéine RAC active, qui est fixée à une GTP; (ii) mettre en contact ou non ladite cellule avec le composé; (iii) déterminer la conversion de la RAC inactive en RAC active en présence ou en l'absence du composé; (iv) sélectionner le composé inhibant la conversion de la RAC inactive en RAC active. Ledit composé est utilisé pour traiter des maladies associées à la perte osseuse.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Centre National de La Recherche Scientifique (cnrs)
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