Substituted 2-naphthoic acids as antagonists of gpr105 activity

Details Substituted 2-naphthoic acids as antagonists of gpr105 activity Substituted 2-naphthoic acids as antagonists of gpr105 activity

C - Chemistry, Metallurgy

07

D

C07D 333/24 (2006.01) A61K 31/192 (2006.01) A61K 31/381 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 63/36 (2006.01) C07C 65/11 (2006.01) C07C 65/24 (2006.01) C07C 65/30 (2006.01) C07C 65/34 (2006.01) C07C 69/76 (2006.01) C07C 317/44 (2006.01) C07C 323/62 (2006.01) C07D 211/34 (2006.01) C07D 211/52 (2006.01) C07D 249/08 (2006.01) C07D 317/60 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2706632

Substituted 2-naphthoic acids of structural formula I are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.

La présente invention concerne des acides 2-naphtoïques substitués représentés par la formule structurelle (I) qui sont efficaces en tant qu'antagonistes de l'activité biologique de la protéine GPR105. Ils se révèlent utiles pour le traitement, la régulation ou la prévention de troubles sensibles à l'antagonisme de ce récepteur, tels que le diabète, en particulier, le diabète de type 2, la résistance à l'insuline, l'hyperglycémie, les troubles lipidiques, l'obésité, l'athérosclérose, et des pathologies associées au syndrome métabolique.

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