Methods to potentiate intravenous estramustine phosphate

Details Methods to potentiate intravenous estramustine phosphate Methods to potentiate intravenous estramustine phosphate

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 9/08 (2006.01) A61K 9/127 (2006.01) A61K 31/335 (2006.01) A61K 31/44 (2006.01) A61K 31/65 (2006.01)

Patent

CA 2295049

Estramustine phosphate is an anti-mitotic chemotherapeutic drug with proven efficacy against cancer. The invention describes methods which potentiate the therapeutic benefit of intravenous estramustine phosphate. The invention provides for intravenous estramustine phosphate to be administrated at a high dosage exceeding 1300 mg as a single dose. Efficacious enhancement of estramustine phosphate pharmacokinetics is thereby achieved. Further provided, estramustine phosphate may be intravenously administered for use in combinational regimens with other chemotherapeutic agent. The therapeutic advantages achieved using the intravenous estramustine phosphate formulation are applicable to treatment of a variety of cancers including prostate cancer, breast cancer, lung cancer, colorectal cancer, pancreatic cancer, ovarian cancer, melanoma, and other cancers.

L'estramustine phosphate est un médicament chimiothérapeutique antimitotique à efficacité prouvée contre le cancer. L'invention concerne des méthodes permettant de potentialiser les avantages thérapeutiques de l'estramustine phosphate intraveineux. L'invention consiste à administrer l'estramustine phosphate intraveineux à haute dose, une seule dose dépassant 1300 mg. On améliore ainsi efficacement la pharmacocinétique de l'estramustine phosphate. L'invention consiste également à administrer l'estramustine phosphate par voie intraveineuse afin de l'utiliser dans des posologies combinées avec d'autres agents chimiothérapeutiques. On peut appliquer les avantages thérapeutiques de la formulation d'estramustine phosphate intraveineux au traitement de divers cancers, notamment le cancer de la prostate, le cancer du sein, le cancer du poumon, le cancer colorectal, le cancer pancréatique, le cancer ovarien, le mélanome, ainsi que d'autres cancers.

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