Difluoromethylene aromatic ethers as inhibitors of glycine...

Details Difluoromethylene aromatic ethers as inhibitors of glycine... Difluoromethylene aromatic ethers as inhibitors of glycine...

C - Chemistry, Metallurgy

07

C

C07C 229/36 (2006.01) A61K 31/197 (2006.01) A61P 25/28 (2006.01) C07C 229/14 (2006.01) C07C 229/18 (2006.01) C07D 235/04 (2006.01) C07D 239/04 (2006.01) C07D 263/04 (2006.01) C07D 265/12 (2006.01) C07D 267/02 (2006.01) C07D 277/62 (2006.01) C07D 281/02 (2006.01) C07D 307/77 (2006.01) C07D 307/78 (2006.01) C07D 311/04 (2006.01) C07D 317/46 (2006.01) C07D 319/16 (2006.01) C07D 333/16 (2006.01)

Patent

CA 2397698

This invention relates to a series of difluoromethylene aromatic ethers of the formula Image wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other central nervous system disorders in mammals, including humans.

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