Substituted sulfonamides and related compounds in the...

Details Substituted sulfonamides and related compounds in the... Substituted sulfonamides and related compounds in the...

C - Chemistry, Metallurgy

07

D

167/208, 260/253

C07D 405/12 (2006.01) A61K 31/425 (2006.01) A61K 31/47 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2019349

64680-542 SUBSTITUTED SULFONAMIDES AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES ABSTRACT Compounds of the formula Image (I) [wherein R1 is quinolyl, benzothiazolyl or benzopyrimidinyl, each optionally substituted, R2 and R3 are each H or OH, Y is CH2O, C2H4 or C2H2; X is CH2, O, S, NH or NR7 (where R7 is alkyl); n is 0-3; Z is CONHW or CON(Me)2; W is SO2Q, COQ or Q; and Q is H, optionally substituted phenyl, alkyl, cycloalkyl, tetrazolyl or thiazolyl] and pharmaceutical compositions comprising them. The compounds are inhibitors of 5-lipoxygenase enzyme and antagonists of leukotriene B4, leukotriene C4, leukotriene D4 and leukotriene E4.

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