Methods for the identification of ikkalpha function and...

Details Methods for the identification of ikkalpha function and... Methods for the identification of ikkalpha function and...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2485184

The invention provides a method for identifying genes involved in the NF- .kappa.B pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF-.kappa.B pathway; determining the level of expression of said gene in a control sample obtained from wild type cells having levels of a component of a biological pathway; selecting genes having a level of expression that are modulated in said experimental sample relative to said wild type sample. The invention also provides a method of treating inflammatory related diseases by modulating the activity of IKK.alpha..

L'invention concerne un procédé d'identification de gènes impliqués dans le processus NF-kB, caractérisé en ce qu'il comprend les étapes suivantes : détermination du niveau d'expression d'un gène dans un échantillon expérimental obtenu sur des cellules à niveaux déficients de composants du processus NF-kB ; détermination du niveau d'expression dudit gène dans un échantillon témoin obtenu sur des cellules de type sauvage à niveaux de composants d'un processus biologique ; sélection de gènes ayant un niveau d'expression, modulés dans ledit échantillon expérimental, par rapport audit échantillon de type sauvage. L'invention concerne également un procédé de traitement de maladies à caractère inflammatoire par modulation de l'activité de IKK.alpha..

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