A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2501295
Disclosed herein are methods for generating proteases with altered specificity for the target molecules they cleave. The invention further discloses methods of using these proteases to treat diseases in which the target proteins are involved with. Cleaving certain target proteins at certain substrate sequences with a protease is a method for treating these pathologies.
L'invention concerne des procédés de production de protéases à spécificité modifiée destinées à des molécules cibles qu'elles clivent. L'invention concerne également des procédés d'utilisation de ces protéases, aux fins de traitement de maladies dans lesquelles les protéines cibles sont impliquées. Une méthode traitement de ces pathologies consiste en un clivage de certaines protéines cibles au niveau de certaines séquences à substrats avec une protéase.
Craik Charles S.
Nguyen Jack
Ruggles Sandra Waugh
Thanos Chris
Catalyst Biosciences Inc.
Regents Of The University Of California
Smart & Biggar
LandOfFree
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