Improved methods and systems for performing molecular...

G - Physics – 01 – N

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G01N 27/447 (2006.01) B01D 57/02 (2006.01) C12N 15/10 (2006.01)

Patent

CA 2309831

The present invention provides methods of electrophoretically separating macromolecular species, as well as compositions and systems useful in carrying out such methods. Specifically, the methods of the present invention comprise providing a substrate that has at least a first capillary channel disposed therein. The surface of the channel has a first surface charge associated therewith, and is filled with a water soluble surface adsorbing polymer solution that bears a net charge that is the same as the charge on the capillary surface.

Cette invention se rapporte à des procédés servant à séparer par électrophorèse des espèces macromoléculaires, ainsi qu'à des compositions et à des systèmes de réalisation de ces procédés. Les procédés de cette invention consistent plus spécifiquement à prendre un substrat dans lequel est ménagé au moins un premier canal capillaire. La surface du canal possède une première charge de surface qui lui est associée et elle est remplie d'une solution polymère adsorbante de surface hydrosoluble qui porte une charge nette qui est identique à la charge s'exerçant à la surface capillaire.

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