Directed switch-mediated dna recombination

Details Directed switch-mediated dna recombination Directed switch-mediated dna recombination

C - Chemistry, Metallurgy

12

N

C12N 15/90 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2248543

Switch regions derived from an immunoglobulin (Ig) gene are used to direct recombination between (1) a targeting construct containing a promoter and a switch region (S1), and (2) a target locus minimally containing a promoter, a switch region (S2), and a target sequence.

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