A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/19 (2006.01) A61K 47/42 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2516028
Provided is a cancer therapeutic agent comprising a cancer targeting molecule linked to a liver-expressed chemokine (LEC). In one embodiment, the cancer targeting molecule is an antibody that targets cancer cells or tumors in vivo. The cancer targeting molecule is associated non-covalently or covalently with LEC. The cancer therapeutic agents of the invention are useful for the treatment of cancer in an individual by reducing the size of a tumor or inhibiting the growth of cancer cells in an individual and/or by inhibiting the development of metastasis. The effectiveness of the therapy using the LEC cancer therapeutic agents can be increased by reducing the activity of immunoregulatory T cells and/or by adoptively transferring immune T cells.
L'invention concerne un agent thérapeutique anticancéreux comprenant une molécule ciblant un cancer liée à une chemokine exprimée par le foie (LEC). Dans un mode de réalisation, la molécule ciblant un cancer est un anticorps qui cible des cellules ou des tumeurs cancéreuses in vivo. La molécule ciblant un cancer est associée de manière covalente ou non covalente à LEC. Les agents thérapeutiques anticancéreux de l'invention sont utilisés pour traiter un cancer chez un individu par réduction de la taille d'une tumeur ou par inhibition de la croissance des cellules cancéreuses et/ou par inhibition du développement des métastases. L'efficacité de la thérapie utilisant des agents thérapeutiques anticancéreux LEC peut être augmentée par réduction de l'activité des lymphocytes T immunorégulateurs et/ou par transfert de lymphocytes T immuns de manière adoptive.
Epstein Alan L.
Hu Peisheng
Li Jiali
Gowling Lafleur Henderson Llp
University Of Southern California
LandOfFree
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