Thienopyridone derivatives as kinase inhibitors

Details Thienopyridone derivatives as kinase inhibitors Thienopyridone derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07D 221/00 (2006.01) C07D 333/00 (2006.01)

Patent

CA 2528603

A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 2- position by a carbonyl- or sulfonyl-linked pyrrolidin-3-yl, pyrrolidin-3- ylamino or related moiety, being inhibitors of p38 MAP kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.

Cette invention concerne une série de dérivés de thiéno[2,3-<i>b</i>]pyridine-6(7<i>H</i>)-one substitués en position 2 par une fraction pyrrolidine-3-yl, pyrrolidine-3-ylamino à liaison carbonyle ou sulfonyle ou une fraction apparentée, qui sont des inhibiteurs de p38 MAP kinase, et qui, de ce fait sont utilisés en en médecine, par exemple pour le traitement et/ou la prévention de troubles immuns ou inflammatoires.

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