Chimeric therapeutic agents

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/22 (2006.01)

Patent

CA 2616551

A fusion protein including (i) a first segment that is located at the amino terminus of the fusion protein and contains the sequence of a first biological active peptide or protein; and (ii) a second segment that is located at the carboxyl terminus of the fusion protein and contains the sequence of a second biological active peptide or protein. The first and second segments are operably and covalently linked. Also disclosed are nucleic acids encoding the fusion protein, vectors and host cells having the nucleic acids, and related composition and methods of treating diabetes or/and obesity.

La présente invention concerne une protéine hybride comprenant (i) un premier segment qui est placé à l'extrémité amino de la protéine hybride et qui contient la séquence d'un premier peptide ou d'une première protéine à activité biologique; et (ii) un second segment qui est placé à l'extrémité carboxyle de la protéine hybride et qui contient la séquence d'un second peptide ou d'une seconde protéine à activité biologique. Le premier et le second segment sont opérationnellement liés par covalence. Cette invention concerne également des acides nucléiques codant pour la protéine hybride, des vecteurs et des cellules hôtes contenant les acides nucléiques, ainsi qu'une composition associée et des méthodes permettant de traiter le diabète et/ou l'obésité.

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