Therapeutic combinations comprising a selective estrogen...

Details Therapeutic combinations comprising a selective estrogen... Therapeutic combinations comprising a selective estrogen...

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 38/29 (2006.01)

Patent

CA 2335078

This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)- 5,6,7,8-tetrahydronaphthalene-2-ol or a pharmaceutically acceptable salt thereof and parathyroid hormone or a biologically active fragment thereof, methods of using such compositions and kits containing such compositions. The compositions are useful for treating musculoskeletal frailty, including osteoporosis, osteoporotic fracture, low bone mass and frailty.

Cette invention concerne des compositions et des procédés pharmaceutiques combinés comprenant (-)-cis-6-phényl-5-(4-(2-pyrrolidin-1-yl-éthoxy)-phényl)-5,6,7,8-tétrahydronaphtalène-2-ol ou un sel acceptable sur le plan pharmaceutique de celui-ci et une hormone parathyroïdienne ou un fragment bioactif de celle-ci, des procédés d'utilisation de ces compositions ainsi que des kits contenant lesdites compositions. Les compositions sont utiles pour traiter la fragilité musculo-squelettique, notamment l'ostéoporose, les fractures ostéoporotiques, la faible masse osseuse et la fragilité.

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