C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/16 (2006.01) C07K 14/29 (2006.01) C07K 16/12 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2284251
Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
La présente invention concerne des composés permettant de diagnostiquer et de traiter l'infection par Ehrlichia, en particulier l'ehrlichiose granulocytaire humaine. Ces composés apportent des polypeptides qui contiennent au moins une portion antigène d'un antigène d'Ehrlichia et des séquences d'ADN codant de tels polypeptides. L'invention concerne également des compositions pharmaceutiques et des vaccins comprenant de tels polypeptides ou de telles séquences d'ADN. L'invention concerne en outre des nécessaires à diagnostic contenant, d'une part de tels polypeptides ou de telles séquences d'ADN, et d'autre part un réactif de détection approprié convenant à la détection de l'infection par Ehrlichia chez des patients et dans des prélèvements biologiques. L'invention concerne enfin des anticorps dirigés contre de tels polypeptides.
Houghton Raymond
Lodes Michael J.
Reed Steven G.
Corixa Corporation
Gowling Lafleur Henderson Llp
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