A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/12 (2006.01) A61K 9/10 (2006.01) A61M 36/14 (2006.01)
Patent
CA 2706111
A homogenous dispersion of aqueous droplets of a radiopharmaceutical or radiodiagnostic agent within a non-aqueous medium and method of making the same is provided. The homogenous dispersion is largely free of impurities and constitutes a substantially uniform distribution of sodium thiosulfate and radiopharmaceutical which is stable for a time sufficient to fill and solidify within gel capsules. In making the homogenous dispersion, dry sodium thiosulfate and dry potassium phosphate dibasic anhydrous are uniformly dispersed within non-aqueous, liquid polyethylene glycol.
L'invention concerne une dispersion homogène de gouttelettes aqueuses d'un agent radiopharmaceutique ou de radiodiagnostic dans un milieu non aqueux, et un procédé de réalisation de celle-ci. La dispersion homogène est largement exempte d'impuretés, et constitue une répartition sensiblement uniforme de thiosulfate de sodium et d'un agent radiopharmaceutique qui est stable pendant une durée suffisante pour remplir et solidifier l'intérieur de capsules de gel. Lors de la réalisation de la dispersion homogène, du thiosulfate de sodium sec et du phosphate de potassium sec dibasique anhydre sont dispersés uniformément dans du polyéthylèneglycol liquide non aqueux.
Oehlberg Peter J.
Schramm Ernst
Bracco Diagnostics Inc.
Bracco Imaging S.p.a.
Heenan Blaikie Llp
LandOfFree
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