Method and apparatus for conducting multiparametric...

Details Method and apparatus for conducting multiparametric... Method and apparatus for conducting multiparametric...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) G01B 9/02 (2006.01) G01N 21/45 (2006.01)

Patent

CA 2241364

The invention relates to a method of identifying the individual autosomal and sex chromosomes of a human karyotype through the use of a set of combinatorially labeled oligonucleotide probes each member thereof: (i) having a predetermined label distinguishable from the label of any other member of said set, and (ii) being capable of specifically hydridizing with one predetermined autosomal or sex chromosome of a human karyotype. The invention additionally relates to an interferometer that is used in such method.

L'invention porte sur un procédé permettant d'identifier les chromosomes autosomiques ainsi que les chromosomes sexuels d'un caryotype humain en utilisant un ensemble de sondes d'oligonucléotides marquées de manière combinatoire: (i) ayant chacune une désignation préétablie se distinguant de celle de n'importe quel autre élément de l'ensemble susmentionné et (ii) étant chacune en mesure de s'hybrider de manière spécifique avec un chromosome autosomique ou un chromosome sexuel prédéfinis d'un caryotype humain. Cette invention a trait, de surcroît, à un interféromètre utilisé dans le cadre de ce procédé.

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