Animal model for hiv induced disease

Details Animal model for hiv induced disease Animal model for hiv induced disease

A - Human Necessities

01

K

A01K 67/00 (2006.01) C12N 15/867 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2635722

HIV does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing, treating or curing disease caused by this virus. The present invention provides compositions and a method for producing an animal model for HIV induced disease. The present invention is an animal adapted to simulate a human-like immune response to HIV, which is accomplished by activation and inactivation of complement of proteins within the animal. Accordingly, the present invention stages certain human proteins within an animal by way of its gut associated lymphoid tissue followed by infection of live HIV.

Le VIH ne cause pas de pathologie chez les espèces non humaines. Ainsi, il n'existe pas de système animal modèle permettant d'évaluer l'efficacité des stratégies ayant pour but de prévenir, traiter ou guérir une pathologie causée par ce virus. La présente invention concerne des compositions et un procédé visant à produire un modèle animal pour une pathologie induite par le VIH. La présente invention concerne un animal apte à simuler une réponse immunitaire au HIV semblable à celle de l'humain, qui est obtenue par activation et désactivation d'un complément protéinique au sein de l'animal. En conséquence, la présente invention concerne la classification de certaines protéines humaines au sein de l'animal par l'intermédiaire du tissu lymphoïde de ses intestins puis une infection par le virus vivant du VIH.

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