Methods for identifying and isolating tissue-specific...

Details Methods for identifying and isolating tissue-specific... Methods for identifying and isolating tissue-specific...

G - Physics

01

N

G01N 33/58 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2409333

This invention provides novel methods of and kits for labeling and isolating lumen-exposed molecules, particularly polypeptides which are expressed in a tissue-specific or organ-specific manner. The methods and kits can be used to isolate molecules exposed on the luminal side of cells lining vascular, ductal, sinus, respiratory, fascial, and other perfusible tissue spaces.

Cette invention a trait à de nouvelles méthodes de marquage et d'isolation, ainsi qu'aux matériels correspondants, de molécules placées côté lumière, notamment des polypeptides exprimés avec spécificité pour un tissu ou un organe. Il est possible d'utiliser ces techniques et les matériels correspondants pour isoler des molécules exposées sur le côté lumière d'espaces du revêtement cellulaire vasculaire, intracanalaire, sinusien, respiratoire, ou des fascias et d'autres espaces tissulaires pouvant être perfusés.

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