Sustained release of microcrystalline peptide suspensions

Details Sustained release of microcrystalline peptide suspensions Sustained release of microcrystalline peptide suspensions

A - Human Necessities

61

K

A61K 38/09 (2006.01) A61K 9/00 (2006.01) A61K 38/31 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/20 (2006.01) A61K 9/10 (2006.01) A61K 9/19 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2459309

The invention relates to a method of preventing gel formation of a hydrophobic peptides by contacting the hydrophobic peptide with a counter-ion in an amount and at a molar ratio sufficient to provide a fluid, milky microcrystalline aqueous suspension of the peptide without formation of a gel. The invention also relates to a fluid, milky microcrystalline aqueous suspension of a hydrophobic peptide and a counter-ion in water, wherein the peptide and counter-ion are present in amounts and at a molar ratio sufficient to form, upon mixing, the suspension without formation of a gel.

Cette invention concerne un procédé destiné à empêcher la formation d'un gel de peptides hydrophobes en mettant en contact ledit peptide hydrophobe avec un contre-ion en quantité et selon un rapport molaire suffisant pour obtenir une suspension aqueuse microcristalline fluide et laiteuse de ce peptide sans formation d'un gel. L'invention concerne également une suspension aqueuse microcristalline fluide et laiteuse du peptide hydrophobe et du contre-ion dans l'eau, le peptide et le contre-ion étant présents en quantité et selon un rapport molaire suffisants pour former, au mélange, une suspension sans formation de gel.

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