Mixed specificity fusion proteins

Details Mixed specificity fusion proteins Mixed specificity fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2099779

Mixed specificity fusion proteins capable of binding to cellular adhesion molecules have been produced. The fusion pro- teins contain a polypeptide region, such as an IgG constant region, operatively attached to at least two binding regions each of which corresponds to either an extracellular domain of a cell surface receptor for cellular adhesion molecules, or a variable re- gion of an antibody directed to a cellular adhesion molecule. A method of inhibiting inflammation in a patient is disclosed in which the present fusion proteins are administered to a patient to inhibit the attachment of inflammatory cells to vascular endo- thelium. A method of inhibiting metastasis is disclosed in which the present fusion proteins are administered to a patient to inhi- bit the metastasis of responsive tumor cells.

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