Sgc stimulators, sgc activators and combinations for the...

A - Human Necessities – 61 – K

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A61K 31/194 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2686906

The invention provides pharmacological compositions comprising a stimulator or activator of the soluble guanylate cyclase alone (sGC) or in combination with a PDE5 inhibitor for the treatment of urological disorders comprising of Benign Prostate Syndrome (BPS), Benign Prostate Hyperplasia (BPH), Benign Prostate Enlargement (BPE), Bladder Outlet Obstruction (BOO), Lower Urinary Tract Symptoms (LUTS), genitourinary disorders comprising neurogenic bladder syndrome (OAB) and (IC), urinary incontinence (UI) like mixed-, urge-, stress-, or overflow incontinence (MUI, UUI, SUI, OUI) and pelvic pain (PP).

La présente invention concerne des compositions pharmaceutiques renfermant un stimulateur ou un activateur de la guanylate cyclase soluble (sGC) seul ou en combinaison avec un inhibiteur de la PDE5 pour le traitement de troubles urologiques comprenant le syndrome prostatique bénin (SPB), l'hyperplasie bénigne de la prostate (HBP), l'hypertrophie bénigne de la prostate (HBP), l'obstruction sous-vésicale, les sténoses urétrales, de troubles génito-urinaires comprenant le syndrome de la vessie neurologique (vessie hyperactive) et (cystite interstitielle), l'incontinence urinaire (IU) comme l'incontinence mixte, par impériosité, d'effort ou par regorgement (IUM, IUI, IUE, IUR) et les douleurs pelviennes (PP).

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