A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/00 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2536827
It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject~s blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically- acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from : (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
On a découvert que l'administration de nitrite à des sujets entraîne une réduction de la pression sanguine et une augmentation du débit sanguin dans les tissus. L'effet est particulièrement bénéfique, par exemple, pour des tissus situés dans des régions à faible tension en oxygène. Cette découverte permet d'élaborer des traitements utiles pour réguler la pression sanguine et le débit sanguin d'un sujet, par exemple, par administration de sels de nitrite. L'invention concerne des méthodes d'administration d'un sel de nitrite acceptable sur le plan pharmaceutique à un sujet, aux fins de traitement, de prévention ou d'amélioration d'un état sélectionné parmi: (a) une blessure d'ischémie-reperfusion (par exemple, une blessure d'ischémie-reperfusion hépatique ou cardiaque ou cérébrale); (b) l'hypertension pulmonaire (par exemple, l'hypertension pulmonaire néonatale); ou (c) l'angiospasme artériel cérébral.
Cannon Richard O. III
Gladwin Mark T.
Hunter Christian J.
Kim-Shapiro Daniel B.
Lefer David J.
Loma Linda University
Smart & Biggar
The Board Of Supervisors Of Louisiana State University And Agric Acting Through Louisiana State University Health
The Government Of The United States Of America As Represented By
University Of Alabama Research Foundation
LandOfFree
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