Novel taxane derivatives, their preparation and compositions...

Details Novel taxane derivatives, their preparation and compositions... Novel taxane derivatives, their preparation and compositions...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2136211

2136211 9323389 Nouveaux dérivés du taxane de formule générale (I), leur préparation et les compositions pharmaceutiques qui les contiennnent. Dans la formule générale (I), Ar représente un radical aryle, R1 représente un atome d'hydrogène ou un radical acétyle ou un radical de formule (II) (R1 et R2 représentent hydrogène, alkyle ou forment ensemble un hétérocycle, n est égal à 2 ou 3); R représente alcoyle, alcényle, alcynyle, cycloalcoyle, cycloalcényle, bicycloalcoyle, phényle ou hétérocyclyle. Les nouveaux produits de formule générale (I) présentent une activité antitumorale remarquable.

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