C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2412592
The use of a compound of formula (I) or a salt, ester or amide thereof; where X is O, or S, S(O) or S(O)2, or NR6 where R6 is hydrogen or C1-6alkyl; R5 is an optionally substituted 5-membered heteroaromatic ring, R1, R2, R3, R4 are independently selected from various specified moieties, in the preparation of a medicament for use in the inhibition of aurora 2 kinase. Certain compounds are novel and these, together with pharmaceutical compositions containing them are also described and claimed.
L'invention concerne un composé de la formule (I) ou d'un sel, d'un ester ou d'un amide de ce dernier, sachant que X représente O, S, S(O) ou S(O)¿2?, ou NR?6¿, R?6¿ représentant de l'hydrogène ou alkyle en C¿1-6?; R?5¿ représente un cycle hétéro-aromatique à 5 chaînons éventuellement substitué ; R?1¿, R?2¿, R?3¿, R?4¿ sont indépendamment sélectionnés parmi divers groupes caractéristiques spécifiques. Ce composé est utilisé dans la préparation d'un médicament permettant l'inhibition de l'aurora 2 kinase. Certains composés sont nouveaux. L'invention les concerne ainsi que des compositions pharmaceutiques les contenant.
Jung Frederic
Mortlock Andrew
Astrazeneca Ab
Smart & Biggar
LandOfFree
Substituted quinazoline derivatives and their use as inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted quinazoline derivatives and their use as inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted quinazoline derivatives and their use as inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1463085