Nicotinamide benzofused-heterocyclyl derivatives useful as...

Details Nicotinamide benzofused-heterocyclyl derivatives useful as... Nicotinamide benzofused-heterocyclyl derivatives useful as...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/665 (2006.01) A61K 31/67 (2006.01) A61K 45/06 (2006.01) C07D 213/00 (2006.01) C07D 271/00 (2006.01) C07D 285/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2398182

Compounds useful as inhibitors of PDE4 in the treatment of diseas s regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructive pulmonary disease, of Formula (1Ø0.). In said formula R5 and R6 are taken together to form a moiety of partial Formulas (1.1.1) through (1.1.5) or a pharmaceutically acceptable salt thereof.

L'invention a trait à des composés utiles comme inhibiteurs de PDE4 dans le traitement de maladies régulées par l'activation et la dégranulation de polynucléaires éosinophiles, spécialement l'asthme, la bronchite chronique et la bronchopneumopathie obstructive chronique ; ou à un sel pharmaceutiquement acceptable de ces composés. Les composés sont représentés par la formule (1Ø0), dans laquelle R<5> et R<6> forment ensemble une fraction des formules partielles (1.1.1) à (1.1.5).

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