Apparatus and methods for assessing metabolic substrate...

G - Physics – 01 – N

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G01N 33/92 (2006.01) G01N 33/50 (2006.01) G01N 33/66 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2546420

Apparatus and methods for assessing metabolic substrate utilization are described. In one embodiment, a processor-readable medium includes code to receive data indicative of a plasma glucose concentration, a plasma free fatty acid concentration, and a respiratory quotient of a subject. The processor- readable medium also includes code to calculate, based on the data, respective values of a set of metabolic parameters. The set of metabolic parameters includes a first metabolic parameter and a second metabolic parameter. The value of the first metabolic parameter is indicative of whether the subject has a predisposition towards oxidation of a first type of metabolic substrate or a second type of metabolic substrate, and the value of the second metabolic parameter is indicative of the subject~s responsiveness to a change in availability of the first typo of metabolic substrate or the second type of metabolic substrate.

L'invention concerne des dispositifs et des procédés pour l'évaluation de l'utilisation de substrat métabolique. Selon une variante, on décrit un support lisible par la machine comprenant un code pour la réception de données indiquant une concentration de glucose dans le plasma, une concentration d'acides gras libres dans le plasma, et un quotient respiratoire chez un sujet. Le support comprend aussi un code de calcul, à partir des données, pour les valeurs respectives d'une série de paramètres métaboliques comprenant un paramètre métabolique et un second paramètre métabolique. La valeur du premier paramètre indique si le sujet a une prédisposition pour l'oxydation d'un premier type de substrat métabolique ou d'un second type de substrat métabolique, et la valeur du second paramètre indique la réactivité du sujet à un changement de disponibilité du premier type de substrat ou du second type de substrat.

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