C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) A61P 9/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2525647
The present invention provides synthetic CXCR3 ligands, including consensus CXCR3 ligands and hybrid CXCR3 ligands; and compositions comprising the ligands. The present invention provides polynucleotides encoding the synthetic CXCR3 ligands; expression vectors comprising the polynucleotides; and host cells comprising the polynucleotidess. The present invention provides methods of treating fibrotic disorders; methods of treating angiogenic disorders; methods of treating cancer; and methods of treating bacterial infections. The methods generally involve administering to an individual in need thereof an effective amount of a subject synthetic CXCR3 ligand.
L'invention concerne des ligands CXCR3 synthétiques, dont des ligands CXCR3 consensus et des ligands CXCR3 hybrides ainsi que des compositions comprenant les ligands. L'invention porte également sur des polynucléotides codant pour les ligands CXCR3 synthétiques ; des vecteurs d'expression comprenant les polynucléotides et des cellules hôtes comprenant lesdits polynucléotides. Elle se rapporte encore à des méthodes de traitement de troubles fibrotiques, à des méthodes de traitement de troubles angiogéniques ; à des méthodes de traitement du cancer et à des méthodes de traitement d'infections bactériennes. Ces méthodes consistent généralement à administrer à un individu en ayant besoin une dose efficace d'un ligand CXCR3 synthétique.
Borden Ladner Gervais Llp
Intermune Inc.
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