Methods and compositions for prevention, diagnosis, and...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 39/385 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2461631

The present invention provides bispecific molecules having a first antigen recognition portion which binds a C3b-like receptor (known as complement receptor 1 (CRl) or CD35 in primates) and a second antigen recognition portion which binds a tumor associated antigen present in the circulation of a mammal. The invention also provides methods of using the bispecific molecules for removing shed tumor associated antigens from the circulation of a mammal. The invention also provides methods of using the bispecific molecules for diagnosis and treatment of cancer.

L'invention se rapporte à des molécules bispécifiques présentant une première partie de reconnaissance de l'antigène qui fixe un récepteur de type C3b (connu comme récepteur de complément 1 (CR1) ou CD35 chez les primates), et une seconde partie de reconnaissance de l'antigène qui fixe un antigène associé à une tumeur et présent dans la circulation d'un mammifère. L'invention se rapporte également à des méthodes d'utilisation des molécules bispécifiques pour éliminer de la circulation d'un mammifère les antigènes associés à une tumeur libérés. En outre, l'invention se rapporte à des méthodes d'utilisation de molécules bispécifiques pour le diagnostic et le traitement du cancer.

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