A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 9/127 (2006.01)
Patent
CA 2250222
The present invention relates to methods for the inhibition, of the gene product of the neu oncogene, p185neu tyrosine kinase. Overexpression of the neu oncogene leads to chemoresistance. The methods disclosed involve the novel use of E1A and/or LT in combination with chemotherapeutic drugs to treat carcinoma. Furthermore, E1A surprisingly potentiates the antineoplastic effects of the chemotherapeutic agents. The inventors propose that E1A sensitizes cancer cells such that they become amenable to treatment by chemotherapeutic drugs.
L'invention porte sur des méthodes d'inhibition du produit génique de l'oncogène neu, la p185neu tyrosine kinase. La surexpression de l'oncogène neu entraîne la chimioésistance. Lesdites méthodes portent sur de nouvelles utilisations de l'E1A et/ou du LT en association avec des médicaments de chimiothérapie pour traiter le carcinome. De plus, l'E1A, de manière surprenante, potentialise les effets antinéoplasiques des agents chimiothérapeutiques. Les inventeurs avancent que l'E1A sensibilise les cellules cancéreuses de manière à les rendre passibles d'un traitement par des médicaments chimiothérapeutiques.
Hung Mien-Chie
Ueno Naoto T.
Bereskin & Parr Llp
Board Of Regents The University Of Texas System
LandOfFree
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